Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism.

Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism.

Magna Labs is proud to announce to have cooperated in an interesting genome-wide association study to discover genetic markers of clozapine plasma concentrations, recently published in the American Journal of Psychiatry. Magna Labs has contributed to this research by performing anonymised clozapine assays to determine clozapine levels. The study has shown that genetic variants exist that have a major effect on clozapine metabolism....

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A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia.

A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia.

Magna Labs has cooperated with its sister organization Leyden Delta and the Cardiff University on a Molecular Psychiatry article on the importance of the Duffy-null genotype for the risk of clozapine-induced neutropenia. The study shows that individuals with the Duffy-null genotype have a significantly increased risk to develop clozapine-induced neutropenia, and stress the potential for a pharmacogenetic test for this genotype as part of the decision to follow BEN monitoring criteria....

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